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                    巧捷公司發現EIF3B在NSCLC惡性表型調控及預后中的重要作用(Cancer Biomarkers)

                    發布時間:  2020.09.03

                    Cancer Biomarkers 23 (2018) 291–300
                    DOI 10.3233/CBM-181628
                    IOS Press

                    EIF3B correlates with advanced disease stages and poor prognosis, and it promotes proliferation and inhibits apoptosis in non-small cell lung cancer

                    Yuan Tiana, Ke Zhao, Luer Yuan, Jialing Li, Shuangbing Feng, Yufeng Feng, Zhongqi Fang,
                    Hui Li and Ruoyu Deng

                    Corresponding author: Ruoyu Deng, Shanghai Qeejen Bio-tech Institution

                    BACKGROUND: Although up-regulation of EIF3B correlates with poor prognosis in carcinomas, the role of EIF3B in nonsmall
                    cell lung cancer (NSCLC) is rarely known.
                    OBJECTIVE:We aimed to investigate correlation of EIF3B with clinicopathological features and prognosis in NSCLC patients,
                    and clarify its effect on cells proliferation and apoptosis.
                    METHODS: Two hundred and eleven NSCLC patients underwent surgery were retrospectively reviewed. Tumor tissue and
                    paired adjacent tissue were obtained. EIF3B expression was detected by immunohistochemistry, qPCR and western blot. EIF3B
                    inhibitor, blank inhibitor, blank mimic and EIF3B mimic plasmids were transfected to A-549 cells. Cells proliferation and apoptosis
                    were measured by CCK-8 and AV/PI. All processes were repeated for validation in PC9 cells.
                    RESULTS: EIF3B expression increased in tumor tissue compared to paired adjacent tissue, and positively correlated with tumor
                    size, lymph node metastasis and TNM stage. K-M curves revealed patients with EIF3B high expression had shorter DFS and OS,
                    and its high expression independently predicted unfavorable DFS and OS. In vitro, EIF3B expression increased in NSCLC cells
                    compared to normal cells. EIF3B increased cells proliferation but inhibited cells apoptosis.
                    CONCLUSIONS: EIF3B overexpression correlates with advanced disease conditions and poor prognosis, and it promotes cells
                    proliferation while inhibits apoptosis in NSCLC.

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                    滬公網安備31011002002896號 2018 上海巧捷生物科技有限公司 All rights reserved. 滬ICP備18017782號-1
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